Glenn Yiu


I am a retinal specialist and clinician-scientist at UC Davis, where I combine clinical practice in vitreoretinal surgery with translational laboratory research studying the pathogenesis and treatment of age-related macular degeneration (AMD), diabetic retinopathy, and other retinal diseases. My research combines ocular imaging with genetic/molecular techniques to develop therapies and disease models of retinal diseases across mice, monkeys, and humans. Our research interests include:

1) Optically-triggered nanoparticles for ocular drug delivery

2) Optogenetic control of oxidative stress to model AMD

3) Multimodal imaging of primate models of AMD

4) CRISPR-based gene editing for neovascular retinal disease

5) Automated screening and deep learning for detection of diabetic retinal diseases

Research Interests: Control theory, dynamical systems, optimization, stochastic processes, cyber-physical systems

As a retinal physician and clinician-scientist with expertise in advanced ocular imaging modalities, I am focused on developing and employing imaging technologies to improving health outcomes. Our research includes the identification of imaging biomarkers to understand disease pathophysiology and progression, employment of deep learning to detect and predict disease, and implementation of these technologies in real-world hospital settings. Our core translational laboratory also focuses on using ocular imaging not just as diagnostic tools, but using light delivery to control genes and drug delivery in the eye as theranostic systems. Together, our hope is to expand the use of non-invasive modalities in the modern era of precision medicine.


Research Thrusts